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What Is Saxenda
Saxenda is the brand name for liraglutide, an injectable medication used for weight management and loss. Here are some key facts about Saxenda: Buy Saxenda online
- It is a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics the effects of the hormone GLP-1.
- Saxenda was approved by the FDA in 2014 as an obesity treatment option for adults with a BMI over 30, or BMI over 27 with at least one weight-related condition.
- It is self-administered once daily by subcutaneous injection using a prefilled pen injector. The starting dosage is 0.6 mg per day gradually increased to 3 mg.
- Saxenda works by suppressing appetite, slowing gastric emptying, and increasing feelings of fullness and satiety after smaller meals.
- Common side effects can include nausea, vomiting, diarrhea, constipation, low blood sugar, dizziness, and stomach pain. Risks may include gallbladder problems, pancreatitis, kidney failure, and thyroid tumors.
- Average weight loss on Saxenda is about 5-10% of body weight compared to placebo over 1 year when combined with diet and exercise. However, weight may be regained once Saxenda.
- It should not be used in those with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. Caution is advised in those with thyroid disease.
- Saxenda is contraindicated in combination with other weight loss medications and is not recommended for use in children under 18 years old.
- As with any weight loss medication, Saxenda is intended to be used along with a reduced-calorie diet and increased physical activity for obesity management.
Uses Of Saxenda
Here are some of the main uses and applications of Saxenda (liraglutide): Buy saxenda online
- Weight loss – The primary use of Saxenda is as a weight loss medication for obese or overweight patients who have failed to lose sufficient weight through diet and exercise alone.
- Appetite suppression – Saxenda suppresses appetite by increasing feelings of fullness, helping patients eat less, and reducing caloric intake.
- Fat loss – By reducing appetite and calorie intake, Saxenda stimulates fat burning and weight/fat reduction in combination with lifestyle changes.
- Obesity treatment – Saxenda is approved specifically as an adjunct treatment for chronic obesity, defined as having a BMI over 30 or a BMI over 27 with comorbidities.
- Glycemic control – As a GLP-1 receptor agonist, Saxenda can help lower blood glucose levels and A1C percentages in patients with type 2 diabetes.
- Pre-diabetes – Saxenda may be used off-label in people with pre-diabetes to help prevent progression to full-blown diabetes through weight loss.
- Insulin resistance – By aiding weight loss, Saxenda can help improve insulin sensitivity and reduce insulin resistance associated with obesity.
- Cholesterol improvement – Losing excess body fat with Saxenda may lead to benefits in lipid profiles like raising HDL and lowering LDL cholesterol.
- Waist circumference reduction – Significant reductions in waist size and abdominal fat have been seen in clinical studies with Saxenda treatment.
- Body composition changes – In addition to overall weight loss, Saxenda may help reduce body fat percentage while retaining or increasing lean muscle mass.
How To Use Saxenda
Here are some guidelines on properly using Saxenda for weight loss: Buy saxenda online
- Take once daily by subcutaneous injection – Saxenda is injected under the skin (subcutaneously) using the provided prefilled pen. Injections are taken once per day, at any time during the day regardless of meals.
- Start at low dose – The starting dosage is 0.6 mg daily for at least one week before gradually titrating up to the 3 mg maintenance dose, to allow the body to adjust and minimize side effects.
- Inject in abdomen, thigh, or arm – Rotate injections between the abdomen, thighs, and upper arms to vary injection sites. Allow sites to fully heal between injections.
- Use thin needles – Use thin gauge needles like 31-33 size to minimize injection pain and irritation. Pinch skin while injecting.
- Store pens correctly – Saxenda pens must be stored in the refrigerator before first use. Do not freeze. After first use, store at room temperature for 30 days.
- Discard after 30 days – Once removed from the fridge, opened Saxenda pens must be discarded after 30 days even if some medication remains.
- Follow dosage schedule – Carefully follow the dosage titration schedule provided. Saxenda is not a fixed-dose drug.
- Monitor side effects – Watch for common gastrointestinal side effects like nausea, vomiting, and diarrhea, and consult your doctor if severe or persistent.
-Combine with lifestyle changes – Saxenda works best when combined with diet, exercise, and behavioral changes for sustained weight loss effects.
- Stop if ineffective – Discontinue Saxenda use if you do not lose at least 5% of body weight after 12-16 weeks on the 3 mg dose.
Benefit Of Saxenda
Here are some of the major benefits that can occur with responsible use of Saxenda for weight loss: Buy saxenda online
- Clinically significant weight loss – Patients in clinical trials lost an average of 5-10% of body weight over 6 months to 1 year compared to placebo.
- Appetite suppression – Saxenda reduces appetite and promotes feelings of fullness and satiety after smaller portions of meals. This supports eating less.
- A1C reduction – Saxenda can lower A1C percentages in those with type 2 diabetes, improving glycemic control.
- Improved lipid profile – Weight loss induced by Saxenda may lead to benefits in cholesterol markers like increased HDL and lowered LDL.
- Waist circumference reduction – Significant decreases in waist size and visceral abdominal fat were observed in studies. This reduces cardiometabolic disease risks.
- Fat loss preservation – Saxenda promotes fat loss while helping preserve or increase lean muscle mass and resting metabolic rate.
- Sustained results – Weight loss induced by Saxenda can be sustained long-term with continued proper diet and exercise.
- Potential diabetes prevention – In those with prediabetes, Saxenda may help prevent progression to type 2 diabetes through sustained weight loss.
- Improved comorbidities – Weight loss can reduce the severity of other obesity-related conditions like hypertension, sleep apnea, and osteoarthritis.
- Enhanced adherence – Saxenda may improve adherence to diet and exercise changes that are also needed for significant weight loss.
- Well-tolerated – Most patients tolerate Saxenda well, with the most common side effects being temporary mild to moderate gastrointestinal symptoms.
Side effects of Saxenda
Here are some of the major effects that can occur when using Saxenda for weight loss: Buy saxenda online
- Weight loss – Saxenda’s primary effect is dose-dependent weight loss in obese or overweight patients when combined with lifestyle changes.
- Appetite suppression – By mimicking GLP-1, Saxenda suppresses appetite and promotes earlier feelings of fullness after eating. This results in reduced food intake.
- Delayed gastric emptying – Saxenda slows down the emptying of the stomach after meals, which also increases feelings of fullness.
- Fat breakdown enhancement – Saxenda stimulates lipolysis, the breakdown of fat for energy, leading to fat loss.
- Muscle preservation – Unlike some weight loss drugs, Saxenda helps preserve or increase muscle mass while losing fat weight.
- Glycemic control – Saxenda can lower blood glucose, and hemoglobin A1C, and improve glycemic control in patients with type 2 diabetes.
- Cholesterol changes – Weight loss from Saxenda may improve cholesterol profiles, lowering LDL and triglycerides while raising HDL.
- Reduced waist circumference – Significant reductions in visceral belly fat and waist circumference are commonly seen with Saxenda treatment.
- Increased satiety hormones – Saxenda raises levels of appetite-regulating hormones like GLP-1, PYY, and oxyntomodulin that promote satiety.
- Gastrointestinal effects – Nausea, vomiting, and diarrhea are common but usually mild side effects that tend to decline over time on Saxenda.
- Smaller meal portions – Saxenda allows patients to feel full and satisfied eating smaller, lower calorie meals which aids weight loss.
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